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Past

Efficacy of a growth hormone receptor antagonist against Melanoma

By Dr Joanna Perry

This project has in vitro evidence demonstrating that growth hormone (GH) stimulation stimulates signal transduction and promotes proliferation in a panel of primary metastatic melanoma cell lines.

Dr Joanna Perry, University of Auckland

About the project

This project has in vitro evidence demonstrating that growth hormone (GH) stimulation stimulates signal transduction and promotes proliferation in a panel of primary metastatic melanoma cell lines, and that GH receptor (GHR) blockade prevents this (unpublished data, Cancer Society funded project). Whether GHR blockade inhibits tumour growth has not been determined. The aim of this project is to determine whether the GH signalling plays a role in regulating tumour growth in a more realistic in vivo situation where systemic production of GH and interactions with factors produced in the tumour microenvironment will come into play.